Phenothiazines: block dopamine D2 receptor in CTZ
-Compazine 5-10mg IV/IM/PO or 25mg PR
-Phenergan 12.5-25mg IV/PO/PR/IM
**Watch for dystonic reactions and restlessness
Prokinetic agents (have dopamine antagonist activity at CTZ) and antichol/antiserotonin
-Reglan 10mg IV/IM/PO
-Good all-purpose agent and great for gastroparesis
-Watch for drowsiness/restlessness/diarrhea
Serotonin receptor antagonists (5HT-3) work in area postrema and intestinal sites
-Zofran (ondansetron)
-Good for peds 0.15mg/kg IV or ODT
-Studied in chemotherapy patients, but very effective in other forms N/V
-Good side effect profile (HA and constipation, does NOT lower sz threshold)
-Expensive, so only use when truly the best agent for the situation
-4mg ODT in omnicell (reserved for peds, patients on chemo, pregnant, or those that failed another anti-emetic
Antihistamines good for N/V secondary to motion sickness and vertigo
-Meclizine 25mg PO qid